PUBLICATIONS研究業績

原著(抜粋)

  • Nakao F, Setoguchi K, Semba Y, Yamauchi T, Nogami J, Sasaki K, Imanaga H, Terasaki T, Miyazaki M, Hirabayashi S, Miyawaki K, Kikushige Y, Masuda T, Akashi K, Maeda T.

    Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance

    Leukemia. 2023 Mar 27. doi: 10.1038/s41375-023-01879-z. Online ahead of print. PubMed

  • Komata Y, Kanai A, Maeda T, Inaba T, Yokoyama A.

    MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins.

    Nat Commun. 2023 Apr 8;14(1):1979. PubMed

  • Swartzel JC, Bond MJ, Pintado-Urbanc AP, Daftary M, Krone MW, Douglas T, Carder EJ, Zimmer JT, Maeda T, Simon MD, Crews CM.

    Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

    ACS Chem Biol. 2022 Jun 24 PubMed

  • Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.

    A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL

    Blood Adv. 2022 Apr 12;6(7):2388-2402. PubMed

  • Sasaki K, Yamauchi T, Semba Y, Nogami J, Imanaga H, Terasaki T, Nakao F, Akahane K, Inukai T, Verhoeyen E, Akashi K, Maeda T.

    Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

    Blood. 2022 Feb 3 ;139(5):748-760. PubMed

  • Yamauchi T, Miyawaki K, Semba Y, Takahashi M, Izumi Y, Nogami J, Nakao F, Sugio T, Sasaki K, Pinello L , Bauer DE, Bamba T, Akashi K , Maeda T.

    Targeting leukemia-specific dependence on the de novo purine synthesis pathway

    Leukemia. 2022 Feb;36(2):383-393. PubMed

  • Sher F, Hossain M, Seruggia D, Schoonenberg V.A.C., Yao Q, Cifani P, Dassama L.M.K., Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver M.C., Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE.

    Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.

    Nat Genet. 2019 Jul;51(7):1149-1159. PubMed

  • Canver M.C., Bauer DE, Maeda T, Pinello L.

    DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways, and protein complexes from CRISPR screens.

    Bioinformatics. 2019 Jun 1;35(11):1981-1984. PubMed

  • Schoonenberg V.A.C., Cole MA, Yao Q, Macias-Trevino C, Sher F, Schupp PG, Canver M.C., Maeda T, Pinello L, Bauer DE.

    CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis.

    Genome Biology. 2018 Oct 19;19(1):169. PubMed

  • Sugio T, Miyawaki K, Kato K, Sasaki K, Yamada K, Iqbal J, Miyamoto T, Oshima K, Maeda T*, Miyoshi H*, Akashi K.*Co-corresponding author.

    Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS.

    Blood Advances. 2018 Sep 11;2(17):2242-2252. PubMed

  • Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg V.A.C., Cole MA, Trevino CM, Ishikawa Y, Yao Qiuming, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.

    Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS enzyme.

    Cancer Cell. 2018 Mar 12;33(3):386-400. PubMed

  • Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.

    Erythropoietin signaling regulates heme biosynthesis.

    Elife. 2017 May 29;6. pii: e24767. PubMed

  • Miyawaki K, Iwasaki H, Jiromaru T, Kusumoto H, Yurino A, Sugio T, Uehara Y, Odawara J, Daitoku S, Kunisaki Y, Mori Y, Arinobu Y, Tsuzuki H, Kikushige Y,Iino T, Kato K, Takenaka K, Miyamoto T, Maeda T, Akashi K.

    Identification of unipotent megakaryocyte progenitors in human hematopoiesis.

    Blood. 2017 Jun 22;129(25):3332-3343. PubMed

  • Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda Τ.

    Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

    Science. 2016 Jan 15;351(6270):285-9. PubMed

  • Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.

    BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

    Nature. 2015 Nov 12;527(7577):192-7. PubMed

  • Norton LG, Ferrando E, Herguido CR, Liu Z, Guiu J, Islam A, Lee SU, Dr. Yan M, Guidos C, Lopez-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

    Notch signal strength controls cell fate in the haemogenic endothelium.

    Nat Commun. 2015 Oct 14;6:8510. doi: 10.1038/ncomms9510. PubMed

  • Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV.

    Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

    Nat Neurosci. 2015 Jul;18(7):978-87. PubMed

  • Guarnerio J, Riccardi L, Taulli R, Maeda T, Wang G, Hobbs RM, Song MS, Sportoletti P, Bernardi R, Bronson RT, Castillo-Martin M, Cordon-Cardo C, Lunardi A, Pandolfi PP.

    A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

    Cancer Discov. 2015 Apr;5(4):396-409. doi: 10.1158/2159-8290. PubMed

  • Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T.

    Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.

    Haematologica. 2015 Apr;100(4):439-51. PubMed

  • Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

    Characterization of genomic deletion efficiency mediated by CRISPR/Cas9 in mammalian cells.

    J Biol Chem. 2014 Jun 6. pii: jbc.M114.564625. PubMed

  • Chen C, Garcia-Santos D, Seguin A, Ishikawa Y, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Zhang Y, Stubbe JA, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Maeda T, Ward DM, Kaplan J, Ponka P, and Paw BH.

    Snx3 regulates recycling of the transferrin receptor and iron assimilation.

    Cell Metab. 2013 Feb 13. PubMed

  • Lee SU, Maeda M, Ishikawa Y, Li SM, Wilson A, Jubb AM, Sakurai N, Weng L, Fiorini E, Radtke F, Yan M, MacDonald HR, Chen CC and Maeda T.

    LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.

    Blood. 2013 Feb 7;121(6):918-29. PubMed

  • Zhang B, Ho YW, Huang Q, Maeda T, Lin A, Lee SU, Holyoake T, Huettner C, Bhatia R.

    Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.

    Cancer Cell. 2012 Apr 17;21(4):577-92. PubMed

  • Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Feldstein J, Tsuzuki S, Bhatia R and Maeda T.

    The LRF transcription factor regulates mature B cell development and the germinal center response in mice.

    J Clin Invest. 2011 Jul 1;121(7):2583-98. PubMed

  • Maeda T*, Ito K*, Merghoub T, Poliseno L, Hobbs R, Wang G, Dong L, Maeda M Dore L, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss J and Pandolfi PP. *Equal contribution.

    LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

    Dev. Cell. 2009 Oct;17(4):527-40. PubMed

  • Maeda T, Merghoub T, Hobbs R, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP.

    Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

    Science. 2007 May 11;316(5826):860-6. PubMed

  • Maeda T, Hobbs R, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.

    Role of the proto-oncogene pokemon in cellular transformation and ARF repression.

    Nature. 2005 Jan 20;433(7023):278-85. PubMed

  • Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H.

    Histone deacetylase 3 associates with and represses the transcription factor GATA-2.

    Blood. 2001 Oct 1;98(7):2116-23. PubMed

  • Maeda T, Towatari T, Kosugi H, Saito H.

    Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells.

    Blood. 2000, 96(12): 3847-56. PubMed

総説

  • Maeda T.

    Regulation of hematopoietic development by ZBTB transcription factors.

    Int J Hematol. 2016 Sep;104(3):310-23. PubMed

  • Lunardi A, Guarnerio J, Wang G, Maeda T* and Pandolfi PP*. *Co-corresponding authors.

    Role of LRF/Pokemon in lineage fate decisions.

    Blood. 2013 Apr 11;121(15):2845-53. PubMed

  • Lee SU and Maeda T.

    POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.

    Immunol Rev. 2012 May;247(1):107-19. PubMed

  • Maeda T, Hobbs R, J, Pandolfi PP.

    The transcription factor Pokemon: a new key player in cancer pathogenesis.

    Cancer Res. 2005 19: 8575-8578. PubMed

その他

  • Maeda T

    CELMoD for ALL: an exciting prospect

    Blood. 2023 Aug 17 PubMed