Our paper on the role of the mTOR pathway in dexamethasone resistance in B-ALL cells has just been published in Blood Neoplasia! Congratulations to Hiroshi and thanks to all our collaborators!

Via CRISPR screen, we identify the mTORC1 pathway as crucial for B-ALL cell sensitivity to dexamethasone.
We also show that dexamethasone transcriptionally regulates factors upstream of mTORC1 signaling, inducing cell death in B-ALL cells.
https://ashpublications.org/bloodneoplasia/article/1/2/100015/515972/Central-role-of-the-mTORC1-pathway




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