ABOUT

The term “precision medicine” has been increasingly used in the past decade, due in part to the rapid progress in “omics” technologies, such as genomics, proteomics and metabolomics.
Our goal is to provide the best patient care in prevention, diagnosis and treatment “with precision” based on the data from system biology, laboratory tests, imaging findings and health records. We collaborate with physicians and scientists across the fields of clinical and basic medicine and serve as a hub to implement precision medicine at Kyushu University.

The Division of Precision Medicine was newly established in March 2020. While precision medicine covers various aspects of medicine, we will focus on “cancer precision medicine” and pursue the following three objectives: 1) the advancement of therapeutic strategies to overcome cancer heterogeneity; 2) the development of novel methods for cancer prevention and 3) the establishment of clinical systems ensuring the timely availability of novel molecular targeted therapies to cancer patients. We welcome physicians, scientists and students who are interested in working together as a team to establish the future of cancer precision medicine.

Takahiro MaedaProfessor, Division of Precision Medicine
Kyushu University Graduate School of Medical Sciences

MEMBERS

Takahiro Maeda M.D., Ph.D.

Professor

ORCID
Research Focus
Hematology/Oncology
Education
1994 M.D. 　Nagoya University School of Medicine
2002 Ph.D.　Nagoya University Post Graduate School of Medicine
Board Certification
1998 Japanese Society of Internal Medicine
2022 Japanese Society of Hematology
Hospital Appointments
1994 Medical residency, JA Aichi Konan Kosei Hospital, Aichi, Japan
1995 Staff physician, Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Aichi, Japan
1998 Staff physician, Department of Hematology, Toyohashi Municipal Hospital, Aichi, Japan
2007 Member, Hematologic Malignancies Program, City of Hope National Medical center, Duarte, CA, USA
2011 Associate Scientist, Hematology Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
2016 Deputy Director, Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
2018 Director, Center for Cellular and Molecular Medicine, Kyushu University Hospital
Academic Appointments
2001 Research Fellow, Cancer Biology and Genetics Program/Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
2005 Research Associate, Cancer Biology and Genetics Program/Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
2007 Assistant Professor, Department of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
2011 Assistant Professor of Medicine, Harvard Medical School, Boston, MA, USA
2012 Affiliated Faculty Member, Harvard Stem Cell Institute, Boston, MA, USA
2012 Member, Dana-Farber/Harvard Cancer Center, Boston, MA, USA
2013 Associate Member, Broad Institute, Cambridge, MA, USA
2016 Associate Professor, Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
2020 Professor, Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Current research support

5R01DK111455
Role: PI
Agency: NIH/NIDDK
Title: Targeting the NuRD complex for fetal globin induction

20H05699
Role: PI
Agency: Japan Society for the Promotion of Science Scientific Research (S)
Title: Development of novel therapeutic strategies for treatment-refractory AML

Takahiro Maeda ORCID

Shigeki Hirabayashi M.D. Ph.D.

Assistant Professor

ORCID
Research Focus
Systems Genomics, Hematology/Oncology
Education
2005 B.Pharm. Nagoya City University Faculty of Pharmaceutical Sciences
2013 M.D. Niigata University School of Medicine
2021 Ph.D. Kyoto University Graduate School of Medicine
Board Certification
2016 Japanese Society of Internal Medicine
2018 Japanese Society of Hematology
2022 Japanese Society for Transplantation and Cellular Therapy
Hospital Appointments
2013 Medical residency, Yokohama City University Hospital, Kanagawa, Japan
2015 Staff physician, Department of Hematology and Oncology, Kyoto University Hospital, Kyoto, Japan
Academic Appointments
2016 Trainee, Riken, Kanagawa, Japan
2017 Junior Research Associate, Riken, Kanagawa, Japan
2020 Research Fellow, Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2021 Research Assistant Professor, Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
2022 Assistant Professor, Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Current research support

22K16323
Grant-in-Aid for Early-Career Scientists
Role: PI
Agency: Japan Society for the Promotion of Science
Title: Identifying novel targets for cancer therapy using genomic data and functional genomics tools

23kk0305027
Project for Promotion of Cancer Research and Therapeutic Evolution
Role: PI
Agency: Japan Agency for Medical Research and Development
Title: Development of a comprehensive CRISPR base editing method for functional annotation of VUS in hereditary immunodeficiency diseases

23ama221423
Program for Promoting Platform of Genomics based Drug Discovery
Role: PI
Agency: Japan Agency for Medical Research and Development
Title: Comprehensive identification of KRAS mutations involved in resistance to KRAS-targeted therapies

ORCID

Yuichiro Semba M.D., Ph.D.

Assistant Professor

ORCID
Research Focus
Hematology/Oncology
Education
2010 M.D. Kyushu University School of Medicine
2018 Ph.D. Kyushu University Graduate School of Medical Sciences
Board Certification
2015 Japanese Society of Internal Medicine
2019 Japanese Society of Hematology
Hospital Appointments
2010 Medical intern, Toranomon Hospital, Tokyo, Japan
2012 Medical residency, Hamanomachi Hospital, Fukuoka, Japan
2012 Medical residency, Department of Hematology and Oncology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
2017 Staff physician, Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
2018 Research Associate, Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
2022 Assistant Professor, Department of Clinical Immunology and Rheumatology / Infectious Disease, Kyushu University Hospital, Fukuoka, Japan
2023 Assistant Professor, Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Academic Appointments
2019 Research Fellowship for Young Scientists (Postdoctoral Fellow), Japan Society for the Promotion of Science
Current research support
22K16303
Grant-in-Aid for Early-Career Scientists
Role: PI
Agency: Japan Society for the Promotion of Science
Title: Identifying novel therapeutic strategies for TP53-mutated AML
仙波 雄一郎 ORCID

Kiyoko Setoguchi-Miyata Ph.D.

Assistant Professor

ORCID
Research Focus
Molecular Biology, Hematology/Oncology
Education
2001 B.S. Kyushu University School of Science
2003 M.S. Kyushu University Graduate School of Science
2007 Ph.D. Kyushu University Graduate School of Science
Academic Appointments
2007 Research Fellow, Medical Research Institute Tokyo Medical and Dental University
2008 Research Fellow, Kyushu University Graduate School of Medical Sciences
2010 Research Fellow, University of California Los Angeles
2014 Research Assistant Professor, Kyushu University Innovation Center for Medical Redox Navigation
2019 Research Assistant Professor, Kyushu University Graduate School of Medical Sciences
Current research support

23K07816
Grant-in-Aid for Scientific Research (C)
Role: PI
Agency: Japan Society for the Promotion of Science
Title: Development of Synergistic Drug Combinations to Overcome Venetoclax Resistance in Acute Myeloid Leukemia

Kiyoko Miyata ORCID

Takuya Morikawa Ph.D.

Postdoctoral Fellow

ORCID
Research Focus
Genome medicine
Education
2015 B.S.　Department of Biology and Chemistry, Faculty of Science, Yamaguchi University
2017 M.S.　Division of Medical Life Sciences, Graduate School of Systems Life Sciences, Kyushu University
2022 Ph.D.　Division of Medical Life Sciences, Graduate School of Systems Life Sciences, Kyushu University
Academic Appointments
2021 Research Fellow, Division of Genomics, Medical Institute of Bioregulation, Kyushu University
2022 Postdoctoral Fellow, Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Current research support

23K15302
Grant-in-Aid for Early-Career Scientists
Role: PI
Agency: Japan Society for the Promotion of Science
Title: Role of the transcription factor ZBTB7A in AML harboring the AML::ETO fusion

Takuya Morikawa ORCID

Hiroshi Imanaga M.D.

[Staff, Center for Cellular and Molecular Medicine, Kyushu University Hospital]

ORCID
Research Focus
Acute Lymphoblastic Leukemia
Education
2014 M.D. Kyushu University School of Medicine
今永 博 ORCID

Tatsuya Terasaki M.D.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
Acute Lymphoblastic Leukemia
Education
2016 M.D. Yamaguchi University School of Medicine
寺崎 達也 ORCID

Manaka Miyazaki M.S.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
Globin Switch
Education
2020 B.S. Kyushu University School of Medicine
2022 M.S. Kyushu University Graduate School of Medicine
ORCID

Yumiko Maeda M.D.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
Therapy-related leukemia, BRCA gene
Education
2016 M.D. Kyushu University School of Medicine
ORCID

Yu Sakata M.D.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
EBV-related tumors, HSCT
Education
2016 M.D. Oita University School of Medicine
ORCID

Masahiro Ohtsu M.D.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
Acute Myeloid Leukemia
Education
2017 M.D. Kyushu University School of Medicine
ORCID

Ryunosuke Noda M.D.

[Ph.D. student, Kyushu University Graduate School of Medical Sciences]

ORCID
Research Focus
Spacial transcriptomics
Education
2017 M.D. Saga University School of Medicine
ORCID

Kanta Shirono Under Graduate Student

[Kyushu University School of Medicine]

Alumni

Takuji Yamauchi M.D., Ph.D.

[Assistant Professor, Kyushu University Hospital]

Kensuke Sasaki M.D., Ph.D.

[Assistant Professor, Kyushu University]

Kohta Miyawaki M.D., Ph.D.

[Assistant Professor, Kyushu University Hospital]

Fumihiko Nakao M.D.

[Staff Physician, Kyushu Medical Center]